Anycubic Kobra 4 Combo vs Prusa Research MK4S

Technical comparison · Fused filament fabrication (FFF/FDM)

In brief

Kobra 4 Combo leads on the available specs (starting with price); MK4S makes sense only for non-technical reasons (availability, support, ecosystem), or if the missing data matters in your case. On the category's overall technical index, Kobra 4 Combo scores 45/100 against 17/100 for MK4S.

Parameter
Prusa Research MK4S MK4S Prusa Research F2 · Intermediate
Identity
Launch year 2026 2025
Use tier F1 — Entry F2 — Intermediate
Price
Price (€) 499 € 999 €
Price updated on 06/2026
Universal specs
Dimensions (W×D×H) (cm) 45.54 × 44.53 × 46.13 cm 50 × 55 × 40 cm
Weight (kg) 13.6 kg
Work area (mm) 260 × 260 mm 250 × 210 mm
Z-axis height (mm) 260 mm 220 mm
Voltage (V) 230 V
Maximum speed 600 mm/s 500 mm/s
Category specs
Footprint X×Y (short side) (mm) 260 mm
Build height Z (mm) 260 mm
Kinematics Cartesian Cartesian
Max nozzle temperature (°C) 300 °C
Max bed temperature (°C) 100 °C
Max print speed (mm/s) 600 mm/s
Enclosed chamber False False
Filament sensor True
Auto bed leveling Mesh
Standard nozzle diameter (mm) 0.4 mm
Multi-extruder False False
Native Klipper True False
Input shaper True
Multicolor printing true True
Multicolor requires accessory false True
Max colors 4
Ecosystem
Cloud dependency No No
Software notes Equipped with Kobra OS firmware. It supports connectivity via USB, Anycubic Slicer, and the Anycubic mobile app for remote print monitoring and control. Integrates AI-based error detection. PrusaSlicer (optimized) and Prusa Connect for remote control. The machine accepts G-code from any slicer (Cura, Simplify3D) and communicates via USB, Ethernet or Wi-Fi using an open Marlin-based protocol. Compatible with OctoPrint and offline management. Does not require a Prusa account to print, unlike machines with proprietary firmware that block features without connection.

The differences that matter

  • Price: Kobra 4 Combo 499 € vs MK4S 999 € — Kobra 4 Combo wins (+100%)
  • Work area: Kobra 4 Combo 260×260 mm vs MK4S 250×210 mm — Kobra 4 Combo wins (+29%)
  • Native Klipper: Kobra 4 Combo yes, MK4S no
  • Multicolor requires accessory: MK4S yes, Kobra 4 Combo no

Which one to choose

Choose Kobra 4 Combo if…

you value price, work area and native klipper.

See the Kobra 4 Combo sheet →

MakerSpecs is an independent atlas. We don't sell products: this comparison links to both sheets, where you'll find complete data and official links.