Kobra S1 Combo vs Neptune 4 Pro

Technical comparison · Fused filament fabrication (FFF/FDM)

In brief

Kobra S1 Combo and Neptune 4 Pro are two fused filament fabrication (fff/fdm) in a similar class. Choose Kobra S1 Combo if closed chamber matters more; choose Neptune 4 Pro if price matters more. On the category's overall technical index, Kobra S1 Combo scores 55/100 against 36/100 for Neptune 4 Pro.

Parameter
Anycubic Kobra S1 Combo Kobra S1 Combo Anycubic F2 · Intermediate
Elegoo Neptune 4 Pro Neptune 4 Pro Elegoo F2 · Intermediate
Identity
Launch year 2025 2023
Use tier F2 — Intermediate F2 — Intermediate
Price
Price (€) 749 € 299 €
Price updated on 06/2026
Universal specs
Dimensions (W×D×H) (cm) 48.4 × 48.4 × 59.3 cm 47.5 × 44.5 × 51.5 cm
Weight (kg) 18 kg 8.9 kg
Work area (mm) 250 × 250 mm 225 × 225 mm
Z-axis height (mm) 250 mm 265 mm
Maximum speed 600 mm/s 500 mm/s
Declared precision 0.05 mm 0.1 mm
Category specs
XY print surface (mm) 250 mm 225 mm
Maximum Z height (mm) 250 mm 265 mm
Kinematics corexy cartesian
Max nozzle temperature (°C) 320 °C 300 °C
Max bed temperature (°C) 120 °C 110 °C
Max print speed (mm/s) 600 mm/s 500 mm/s
Closed chamber True False
Filament sensor True True
Auto leveling mesh mesh
Standard nozzle diameter (mm) 0.4 mm 0.4 mm
Multi-extruder False False
Native Klipper False True
Input shaper True True
Multicolor printing True False
Requires external accessory False False
Maximum colors 1
Ecosystem
Cloud dependency No No
Software notes The printer works with Anycubic Slicer Next, derived from OrcaSlicer and optimized for the Anycubic ecosystem; it supports multi-plate management and object skipping during printing. Remote control and real-time monitoring are available through the Anycubic app (iOS and Android), connecting via LAN or cloud. The proprietary firmware is not currently open source; native Klipper compatibility is not supported. The machine is driven by Klipper firmware pre-installed on a proprietary 64-bit motherboard, ensuring rapid processing for advanced features like input shaping and pressure advance. The manufacturer provides a customized version of Cura (Elegoo Cura), but the printer is fully compatible with major third-party slicers such as PrusaSlicer and OrcaSlicer. Connectivity includes USB ports and a LAN network port, enabling remote management and direct print file transfers via the Fluidd or Mainsail web interfaces integrated into the system.

The differences that matter

  • Price: Kobra S1 Combo 749 € vs Neptune 4 Pro 299 € — Neptune 4 Pro wins (+151%)
  • Closed chamber: Kobra S1 Combo yes, Neptune 4 Pro no
  • Native Klipper: Neptune 4 Pro yes, Kobra S1 Combo no
  • Multicolor printing: Kobra S1 Combo yes, Neptune 4 Pro no
  • Work area: Kobra S1 Combo 250×250 mm vs Neptune 4 Pro 225×225 mm — Kobra S1 Combo wins (+23%)

Which one to choose

Choose Kobra S1 Combo if…

you value closed chamber, multicolor printing and work area. «A closed chamber reduces thermal gradients around the part being built, limiting warping and cracking caused by rapid cooling in high-shrinkage materials such as ABS, ASA, and PC. It also shields the mechanism from drafts and airborne particles. A closed chamber is effectively necessary for technical materials; for PLA and PETG it is an advantage, not a requirement.»

See the Kobra S1 Combo sheet →

Choose Neptune 4 Pro if…

you value price, native klipper and maximum z height. «Klipper is an open-source firmware that offloads trajectory calculations from the microcontroller to a host computer, enabling all advanced features including input shaper and pressure advance. Native support eliminates the need to replace the firmware, a process that voids the warranty on some machines. Relevant for users who intend to tune advanced parameters; for basic use the difference from Marlin is minimal.»

See the Neptune 4 Pro sheet →

MakerSpecs is an independent atlas. We don't sell products: this comparison links to both sheets, where you'll find complete data and official links.